Hopp til innhold
NHI.no
Annonse

Brucellose: Prognose

Innhold i artikkelen

Inkubasjonstiden, tiden fra smitte til symptomdebut, er lang, ofte 2-8 uker, men den kan også være så kort som en uke. Sykdommen kan ha et kronisk svingende forløp. Men prognosen er vanligvis god. En regner også med at mange sykdomstilfeller forblir uoppdaget og går over av seg selv.

Annonse

I unntakstilfeller kan man få bakteriespredning til de fleste organer i kroppen. De mest vanlige komplikasjoner er bein- og leddangrep (betennelser), betennelser i innerste lag av hjertet, og betennelser i hjernehinner/hjerne. Betennelser i hjertet forekommer hos mindre enn 1%, men er den formen som kan være livstruende.

Vil du vite mer

Dette dokumentet er basert på det profesjonelle dokumentet Brucellose . Referanselisten for dette dokumentet vises nedenfor

  1. Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352: 2325-36. PubMed
  2. Smittevernveilederen. Brucellose - veileder for helsepersonell. Folkehelseinstituttet, sist oppdatert 12.01.2019. fhi.no
  3. Pappas G, Papadimitriou P, Akritidis N, Christou L et al. The new global map of brucellosis. Lancet infect Dis 2006; 6: 91-99. PubMed
  4. Kittang BR, Chelsom J, Jenum PA, Slettebakk Vie W, Wendelbo Ø. Brucellose - en sjelden zoonose. Tidsskr Nor Lægeforen 2003; 123: 2705-7. PubMed
  5. Arenas GN, Staskevich AS, Aballay A, Mayorga LS. Intracellular trafficking of Brucella abortus in J774 macrophages. Infect Immun 2000; 68: 4255-63. PubMed
  6. Gorvel JP, Moreno E. Brucella intracellular life: from invasion to intracellular replication. Vet Microbiol 2002; 90: 281-297. PubMed
  7. Pappas G, Kitsanou M, Christou L, Tsianos E. Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella-induced thrombocytopenia. Am J Hematol 2004; 75: 139-41. PubMed
  8. Beeching NJ, Gerada A, Thomas S. Brucellosis. BMJ Best Practice. Last updated: December 2017.
  9. Almuneef M, Memish ZA. Prevalence of Brucella antibodies after acute brucellosis. J Chemother 2003; 15: 148-51. PubMed
  10. Vrioni G, Pappas G, Priavali E, et al. An eternal microbe: Brucella DNA load persists for years after clinical cure. Clin Infect Dis. 2008;46:e131-e136.
  11. Probert WS, Schrader KN, Khuong NY, Bystrom SL, Graves MH. Real-time multiplex PCR assay for detection of Brucella spp., B. abortus, and B. melitensis. J Clin Microbiol 2004; 42: 1290-3. PubMed
  12. Queipo-Ortuno MI, Colmenero JD, Baeza G, Morata P. Comparison between LightCycler Real-Time Polymerase Chain Reaction (PCR) assay with serum and PCR-enzyme-linked immunosorbent assay with whole blood samples for the diagnosis of human brucellosis. Clin Infect Dis 2005; 40: 260-4. PubMed
  13. Memish Z, Mah MW, Al Mahmoud S, Al Shaalan M, Khan MY. Brucella bacteraemia: clinical and laboratory observations in 160 patients. J Infect 2000; 40: 59-63. PubMed
  14. World Health Organization. Brucellosis in humans and animals. 2006. Last accessed 26 August 2016. www.who.int
  15. Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, et al. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev 2012 Oct 17; 10: CD007179 Cochrane (DOI)
  16. Al-Tawfiq JA. Therapeutic options for human brucellosis. Expert Rev Anti Infect Ther 2008; 6:109. PubMed
  17. Solera J, Martinez-Alfaro E, Espinosa A, Castillejos ML, Geijo P, Rodriguez-Zapata M. Multivariate model for predicting relapse in human brucellosis. J Infect 1998; 36: 85-92. PubMed
  18. Bosilkovski M, Krteva L, Caparoska S, Dimzova M. Hip arthritis in brucellosis: a study of 33 cases in the Republic of Macedonia (FYROM). Int J Clin Pract 2004; 58: 1023-7. PubMed
  19. Reguera JM, Alarcon A, Miralles F, Pachon J, Juarez C, Colmenero JD. Brucella endocarditis: clinical, diagnostic, and therapeutic approach. Eur J Clin Microbiol Infect Dis 2003; 22: 647-50. PubMed
  20. Navarro-Martinez A, Solera J, Corredoira J, et al. Epididymoorchitis due to Brucella mellitensis: a retrospective study of 59 patients. Clin Infect Dis 2001; 33: 2017-22. PubMed
  21. Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37: e95-e99.
  22. Ariza J, Pigrau C, Canas C, et al. Current understanding and management of chronic hepatosplenic suppurative brucellosis. Clin Infect Dis 2001; 32: 1024-33. PubMed
Annonse
Annonse