Brucellose: Årsaker
Sykdommen forårsakes av flere bakterier av arten Brucella. Bakterien smitter først og fremst ved inntak av ikke-pasteuriserte melkeprodukter, det vil si melk eller ost. Men kan også smitte ved direkte eller indirekte kontakt med kveg, geit, sau eller svin. Slakteriarbeidere, bønder og veterinærer i land der brucellose forekommer, er i større risiko enn andre for å få sykdommen. Smitte fra menneske til menneske forekommer i praksis ikke.
Annonse
Inkubasjonstiden, det vil si tiden fra smitte til sykdomstegn, er variabel. I de fleste tilfeller kommer symptomene mellom to og åtte uker etter smitte.
Vil du vite mer
Dette dokumentet er basert på det profesjonelle dokumentet Brucellose . Referanselisten for dette dokumentet vises nedenfor
Referanser
- Pappas G, Akritidis N, Bosilkovski M, Tsianos E. Brucellosis. N Engl J Med 2005; 352: 2325-36. PubMed
- Smittevernveilederen. Brucellose - veileder for helsepersonell. Folkehelseinstituttet, sist oppdatert 12.01.2019. fhi.no
- Pappas G, Papadimitriou P, Akritidis N, Christou L et al. The new global map of brucellosis. Lancet infect Dis 2006; 6: 91-99. PubMed
- Kittang BR, Chelsom J, Jenum PA, Slettebakk Vie W, Wendelbo Ø. Brucellose - en sjelden zoonose. Tidsskr Nor Lægeforen 2003; 123: 2705-7. PubMed
- Arenas GN, Staskevich AS, Aballay A, Mayorga LS. Intracellular trafficking of Brucella abortus in J774 macrophages. Infect Immun 2000; 68: 4255-63. PubMed
- Gorvel JP, Moreno E. Brucella intracellular life: from invasion to intracellular replication. Vet Microbiol 2002; 90: 281-297. PubMed
- Pappas G, Kitsanou M, Christou L, Tsianos E. Immune thrombocytopenia attributed to brucellosis and other mechanisms of Brucella-induced thrombocytopenia. Am J Hematol 2004; 75: 139-41. PubMed
- Beeching NJ, Gerada A, Thomas S. Brucellosis. BMJ Best Practice. Last updated: December 2017.
- Almuneef M, Memish ZA. Prevalence of Brucella antibodies after acute brucellosis. J Chemother 2003; 15: 148-51. PubMed
- Vrioni G, Pappas G, Priavali E, et al. An eternal microbe: Brucella DNA load persists for years after clinical cure. Clin Infect Dis. 2008;46:e131-e136.
- Probert WS, Schrader KN, Khuong NY, Bystrom SL, Graves MH. Real-time multiplex PCR assay for detection of Brucella spp., B. abortus, and B. melitensis. J Clin Microbiol 2004; 42: 1290-3. PubMed
- Queipo-Ortuno MI, Colmenero JD, Baeza G, Morata P. Comparison between LightCycler Real-Time Polymerase Chain Reaction (PCR) assay with serum and PCR-enzyme-linked immunosorbent assay with whole blood samples for the diagnosis of human brucellosis. Clin Infect Dis 2005; 40: 260-4. PubMed
- Memish Z, Mah MW, Al Mahmoud S, Al Shaalan M, Khan MY. Brucella bacteraemia: clinical and laboratory observations in 160 patients. J Infect 2000; 40: 59-63. PubMed
- World Health Organization. Brucellosis in humans and animals. 2006. Last accessed 26 August 2016. www.who.int
- Yousefi-Nooraie R, Mortaz-Hejri S, Mehrani M, et al. Antibiotics for treating human brucellosis. Cochrane Database Syst Rev 2012 Oct 17; 10: CD007179 Cochrane (DOI)
- Al-Tawfiq JA. Therapeutic options for human brucellosis. Expert Rev Anti Infect Ther 2008; 6:109. PubMed
- Solera J, Martinez-Alfaro E, Espinosa A, Castillejos ML, Geijo P, Rodriguez-Zapata M. Multivariate model for predicting relapse in human brucellosis. J Infect 1998; 36: 85-92. PubMed
- Bosilkovski M, Krteva L, Caparoska S, Dimzova M. Hip arthritis in brucellosis: a study of 33 cases in the Republic of Macedonia (FYROM). Int J Clin Pract 2004; 58: 1023-7. PubMed
- Reguera JM, Alarcon A, Miralles F, Pachon J, Juarez C, Colmenero JD. Brucella endocarditis: clinical, diagnostic, and therapeutic approach. Eur J Clin Microbiol Infect Dis 2003; 22: 647-50. PubMed
- Navarro-Martinez A, Solera J, Corredoira J, et al. Epididymoorchitis due to Brucella mellitensis: a retrospective study of 59 patients. Clin Infect Dis 2001; 33: 2017-22. PubMed
- Pappas G, Bosilkovski M, Akritidis N, Mastora M, Krteva L, Tsianos E. Brucellosis and the respiratory system. Clin Infect Dis 2003; 37: e95-e99.
- Ariza J, Pigrau C, Canas C, et al. Current understanding and management of chronic hepatosplenic suppurative brucellosis. Clin Infect Dis 2001; 32: 1024-33. PubMed