Hopp til innhold
NHI.no
Annonse

Forekomst av aktinisk keratose

Innhold i artikkelen

Personer som har vært eksponert for intenst sollys over mange år, har størst risiko. Mer enn 80 prosent av de aktiniske keratosene forekommer på de hudområdene som er mest utsatt for sollys, som hodet, halsen, underarmene og hendene. Tilstanden forekommer oftere med økende alder, og er hyppigere hos menn og hos personer med lys hud. I en studie i Nederland fant man minst en aktinisk keratose hos 38 prosent av alle som ble undersøkt i aldersgruppen over 50 år.

Annonse

Vil du vite mer

  1. Berner Aa. Aktinisk keratose og utvikling av plateepitelkarsinom i hud. Tidsskr Nor Lægeforen 2005; 125: 1653-4. PubMed
  2. Pinkus H. Keratosis senilis: a biological concept of its pathogenesis and diagnosis based on the study of normal epidermis and 1730 seborrhoic and senile keratoses. Am J Clin Pathol 1958; 29: 193-207. PubMed
  3. Moller R, Reymann F, Hou-Jensen K. Metastases in dermatological patients with squamous cell carcinoma. Arch Dermatol 1979; 115: 703-5. PubMed
  4. Lund HZ. How often does squamous cell carcinoma of the skin metastasize? Arch Dermatol 1965; 92: 635-7. PubMed
  5. Dinehart SM, Nelson-Adesokan P, Cockerell C, Russell S, Brown R. Metastatic cutaneous squamous cell carcinoma derived from actinic keratosis. Cancer 1997; 79: 920-3. PubMed
  6. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988; 1: 795-7. PubMed
  7. Moy RL. Clinical presentation of actinic keratosis and squamous cell carcinoma. J Am Acad Dermatol 2000; 42: 8-10. PubMed
  8. Mittelbronn MA, Mullins DL, Ramos Caro FA et al. Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma. Int J Dermatol 1998; 37: 677-81. PubMed
  9. McIntyre WJ, Downs MR, Bedwell SA. Treatment options for actinic keratoses. Am Fam Physician 2007; 76: 667-71. PubMed
  10. Simmonds WL. Topical management of actinic keratoses with 5-fluorouracil: results of a 6-year follow-up study. Cutis 1972; 10: 737-41. PubMed
  11. Stockfleth E, Christophers E, Benninghoff B, Sterry W. Low incidence of new actinic keratoses after topical 5% imiquimod cream treatment: a long-term follow-up study. Arch Dermatol 2004; 140: 1542. PubMed
  12. Pierre P, Weil E, Chen S. Cryotherapy versus topical cryotherapy of actinic keratosis. A systematic review. Allergologie 2001; 24: 204-205. PubMed
  13. Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther 2002; 24: 990-1000. PubMed
  14. Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000; 42: 4-7. PubMed
  15. Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004; 50: 714-21. PubMed
  16. Stockfleth E, Meyer T, Benninghoff B, et al. A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol 2002; 138: 1498-502. PubMed
  17. Szeimies RM, Gerritsen MJ, Gupta G, Ortonne JP, Serresi S, Bichel J, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from a phase III, randomized, double-blind, vehicle-controlled, clinical trial with histology. J Am Acad Dermatol 2004; 51: 547-55. PubMed
  18. Dodson JM, DeSpain J, Hewett JE, Clark DP. Malignant potential of actinic keratoses and the controversy over treatment. A patient-oriented perspective. Arch Dermatol 1991; 127: 1029-31. PubMed
  19. Lubritz RR, Smolewski SA. Cryosurgery cure rate of actinic keratoses. J Am Acad Dermatol 1982; 7: 631-2. PubMed
  20. Fu W, Cockerell CJ. The actinic (solar) keratosis. A 21st-century perspective. Arch Dermatol 2003; 139: 66-70. PubMed
  21. Jorizzo J, Weiss J, Furst K, VandePol C, Levy SF. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: a randomized, vehicle-controlled clinical trial. Arch Dermatol 2004; 140: 813-6. PubMed
  22. Tarstedt M, Rosdahl I, Berne B, Svanberg K, Wennberg AM. A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. Acta Derm Venereol 2005; 85: 424-8. PubMed
  23. Radakovic-Fijan S, Blecha-Thalhammer U, Kittler H, Honigsmann H, Tanew A. Efficacy of 3 different light doses in the treatment of actinic keratosis with 5-aminolevulinic acid photodynamic therapy: a randomized, observer-blinded, intrapatient, comparison study. J Am Acad Dermatol 2005; 53: 823-7. PubMed
  24. Marks R, Rennie G, Selwood TS. Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1988; 1: 795-7. PubMed
  25. Szeimies RM, Karrer S, Radakovic-Fijan S, Tanew A, Calzavara-Pinton PG, Zane C, et al. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: a prospective, randomized study. J Am Acad Dermatol 2002; 47: 258-62. PubMed
Annonse
Annonse