Alkoholisk leverskade: Behandling
Hensikten med behandlingen er å stoppe den videre utvikling av leversykdommen for å forhindre leversvikt. Den aller viktigste og helt nødvendige behandlingen er at inntaket av alkohol stanses. Man må også sørge for god ernæring og rikelig væskeinntak. Ulike medikamenter kan forsøkes, spesielt glukokortikoider, men de må brukes med forsiktighet.
Annonse
Ved akutt leverbetennelse behøver pasienten vanligvis innleggelse i sykehus.
Dette dokumentet er basert på det profesjonelle dokumentet Leversykdom, alkoholisk . Referanselisten for dette dokumentet vises nedenfor
Referanser
- Friedman SL. Management and prognosis of alcoholic hepatitis. UpToDate, last updated Aug 28, 2018. UpToDate
- Blachier M, Leleu H, Peck-Radosavljevic M, et al. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 2013; 58:593. PubMed
- Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH. ACG Clinical Guideline: Alcoholic Liver Disease. Am J Gastroenterol. 2018;113(2):175-194. doi:10.1038/ajg.2017.469 DOI
- O'Shea RS, Dasarathy S, McCullough AJ et. al. Alcoholic liver disease. Hepatology 2010; 51: 307-28. PubMed
- Scholz T, Karlsen TH, Sanengen T, et.al . Levertransplantasjon i Norge gjennom 25 år. Tidsskr Nor Legeforen 2009; 129: 2587-92. Tidsskrift for Den norske legeforening
- Friedman SL. Pathogenesis of alcoholic liver disease. UpToDate, last updated Sep 14, 2018. UpToDate
- Buzzetti E, Kalafateli M, Thorburn D, et al. Pharmacological interventions for alcoholic liver disease (alcohol-related liver disease): an attempted network meta-analysis. Cochrane Database Syst Rev. 2017; 3: CD011646. PMID: 28368093 PubMed
- Pavlov CS, Varganova DL, Casazza G, Tsochatzis E, Nikolova D, Gluud C. Glucocorticosteroids for people with alcoholic hepatitis. Cochrane Database of Systematic Reviews 2017, Issue 11. Art. No.: CD001511. pub3. PMID: 29096421 PubMed
- Whitfield K, Rambaldi A, Wetterslev J, Gluud C. Pentoxifylline for alcoholic hepatitis. Cochrane Database of Systematic Reviews 2009, Issue 4. Art. No.: CD007339. DOI: 10.1002/14651858.CD007339.pub2 DOI
- Thursz MR, Richardson P, Allison M, et al. Prednisolone or Pentoxifylline for Alcoholic Hepatitis. N Engl J Med 2015; 372: 1619-28. doi:10.1056/NEJMoa1412278 DOI
- Groszmann RJ, Garcia-Tsao G, Bosch J, et al, for the Portal Hypertension Collaborative Group. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 2005; 353: 2254-61. New England Journal of Medicine
- Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila FI, Soares-Weiser K, Uribe M. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding. Cochrane Database of Systematic Reviews 2010, Issue 9. Art. No.: CD002907. DOI: 10.1002/14651858.CD002907.pub2 DOI
- Helland A, Bramness JG. Baklofen ved alkoholavhengighet. Tidsskr Nor Legeforen 2011; 131: 2132-3 . doi:10.4045/tidsskr.11.0584 DOI
- Webb K, Neuberger J. Transplantation for alcoholic liver disease (ed.). BMJ 2004; 329: 63-64. PubMed
- Lim J, Curry MP, Sundaram V. Risk factors and outcomes associated with alcohol relapse after liver transplantation. World J Hepatol 2017; 9:771. PubMed
- Pageaux GP, Bismuth M, Perney P, Costes V, Jaber S, Possoz P, et al. Alcohol relapse after liver transplantation for alcoholic liver disease: does it matter? J Hepatol 2003;38: 629-34. PubMed
- Dumortier J, Dharancy S, Cannesson A, et al. Recurrent alcoholic cirrhosis in severe alcoholic relapse after liver transplantation: a frequent and serious complication. Am J Gastroenterol 2015; 110:1160. PubMed
- Yu CH, Xu CF, Ye H, et al. Early mortality of alcoholic hepatitis: a review of data from placebo-controlled clinical trials. World J Gastroenterol 2010; 16:2435. PubMed
- Mathurin P, O'Grady J, Carithers RL, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 2011; 60:255. Gut
- Mezey E, Potter JJ, Rennie-Tankersley L, et al. A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J Hepatol 2004; 40:40. PubMed