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Hepatitt C: Forløp

Forløpet av en hepatitt-C infeksjon uten behandling er bare delvis kjent. En regner med at rundt en av fire blir kvitt viruset av seg selv, mens resten utvikler en kronisk infeksjon. Det er funnet at to av ti pasientene med kronisk hepatitt C vil utvikle komplikasjoner innen 20 til 30 år etter smitte dersom infeksjonen ikke behandles. Andelen fortsetter å øke med økende tid etter smitte. Komplikasjonene er økende grad av leverbetennelse, skrumplever, leversvikt og i noen få tilfeller leverkreft. Levertransplantasjon kan være aktuelt i noen tilfeller.

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Med den medikamentelle behandlingen som nå tilbys alle med kronisk infeksjon, vil de aller fleste bli helbredet fra sykdommen og unngå alle komplikasjonene. 

Dette dokumentet er basert på det profesjonelle dokumentet Hepatitt C . Referanselisten for dette dokumentet vises nedenfor

  1. Folkehelseinstituttet. Hepatitt C - veileder for helsepersonell. Sist oppdatert 02.04.2019. https
  2. Grebely J, Page K, Saks-Davis R. The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection. Hepatology 2014; 69: 109. pmid:23908124 PubMed
  3. Den norske legeforening. Faglig veileder for oppfølging og behandling av hepatitt C hos voksne. 7. mars 2017. beta.legeforeningen.no
  4. Helsedirektoratet. Hepatitt C. Nasjonale faglige råd. Publisert april 2019. www.helsedirektoratet.no
  5. Dalgard O, Egeland A, Ervik R, et al. Risikofaktorer for hepatitt C-smitte blant sprøytemisbrukere. Tidsskr Nor Legeforen 2009; 129: 101-4. Tidsskrift for Den norske legeforening
  6. Bradshaw D, Matthews G, Danta M. Sexually transmitted hepatitis C infection: the new epidemic in MSM? Curr Opin Infect Dis 2013;26:66-72. PMID: 23242342 PubMed
  7. Vik IS, Skaug K, Dalgard O. Hepatitt C - et helseproblem også i Norge. Tidsskr Nor Legeforen 2008; 128: 563. Tidsskrift for Den norske legeforening
  8. WHO. Hepatitis C. Last updated 27 July 2020. www.who.int
  9. Moradpour D, Penin F. Hepatitis C proteins: from structure to function. Curr Top Microbiol Immunol 2013; 369: 113. pmid:23463199 PubMed
  10. Smith DG, Bukh J, Kuiken C. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology 2014; 59: 318. pmid:24115039 PubMed
  11. Horner SM, Gale M. Intracellular Innate Immune Cascades and Interferon Defenses That Control Hepatitis C Virus. J Interferon Cytokine Res 2009; 9: 489. pmid:2956657 PubMed
  12. Lindenbach BD, Rice CM. Unravelling hepatitis C virus replication from genome to function. Nature 2005; 436: 933. pmid:16107832 PubMed
  13. Patel K, Muir AJ, McHutchison JG. Diagnosis and treatment of chronic hepatitis C infection. BMJ 2006; 332: 1013-7. PubMed
  14. Armstrong GL, Alter MJ, McQuillan GM. The past incidence of hepatitis C virus infection: implications for the future burden of chronic liver disease in the United States. Hepatology 2000; 3: 777. pmid:10706572 PubMed
  15. Thomas DL, Thio CL, Martin MP. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus.. Nature 2009; 461: 798. pmid:19759533 PubMed
  16. Paintsil E, He H, Peters C, Lindenbach BD, Heimer R. Survival of hepatitis C virus in syringes: implcation for transmission among injection drug users. J Infect Dis 2010; 202: 984-90. PubMed
  17. Terrault NA, Dodge JL, Murphy EL. Sexual transmission of hepatitis C virus among monogamous heterosexual couples: the HCV partners study. Hepatology 2013; 57: 881. pmid:23175457 PubMed
  18. Witt MD, Saeberg EC, Darilay A. Incident hepatitis C virus infection in men who have sex with men: a prospective cohort analysis, 1984-2011. Clin Infect Dis 2013; 57: 77. pmid:23532480 PubMed
  19. Denniston MM, Jiles RB, Drobeniuc J, et al. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160:293-300. PubMed
  20. Martinez-Bauer E, Forns X, Armellas M. Hospital admission is a relevant source of hepatitis C virus acquisition in Spain. J Hapatol 2008; 48: 20. pmid:17998149 PubMed
  21. Indolfi G, Resti M. Perinatal transmission og hepatitis C virus infection. JMed Virol 2009; 81: 836-43. PubMed
  22. Dalgard O, Konopski Z, Bosse FJ, et. al. Hepatitt C - utredning og behandling. Tidsskr Nor Legeforen 2011; 131: E1-8. Tidsskrift for Den norske legeforening
  23. Pembrey L, Newell ML, Tovo PA et al. The management of HCV infected pregnant women and their children European paediatric HCV network. J Hepatol 2005; 43: 515-25. PubMed
  24. Vanhommerig JW, Thomas XV, van der Meer JTM, et al. Hepatitis C virus (HCV) antibody dynamics following acute HCV infection and reinfection among HIV-infected men who have sex with men. Clin Infect Dis 2014; 59:1678. doi:10.1093/cid/ciu695
  25. Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014;61(1 Suppl):S58–S68. PMID: 25443346 PubMed
  26. Calvaruso V, Cabibbo G, Cacciola I, et al. Incidence of hepatocellular carcinoma in patients with HCV-associated cirrhosis treated with direct-acting antiviral agents. Gastroenterology 2018. pmid:29655836 PubMed
  27. Nelson PK, Mathers BM, Cowie B, et al. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet 2011; 378: 571-83. PubMed
  28. Aleman S, Rahbin N, Weiland O, et al. A risk for hepatocellular carcinoma persists long-term after sustained virologic response in patients with hepatitis C–associated liver cirrhosis. Clin Infect Dis 2013; 57: 230-6. doi:10.1093/cid/cit234
  29. Carrat F, Fontaine H, Dorival C, et al. Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study. Lancet 2019. pmid:30765123 PubMed
  30. Giordano TP, Henderson L, Landgren O, et al. Risk of non-Hodgkin lymphoma and lymphoprolierative precursor disease in UA veterans with hepatitis C virus. JAMA 2007; 297: 2010-7. Journal of the American Medical Association
  31. Pakpoor J, Noyce A, Goldacre R, et al. Viral hepatitis and Parkinson disease: A national record-linkage study. Neurology 2017. PMID: 28356465 PubMed
  32. Midgard H, Weir A, Palmateer N, et al. HCV epidemiology in high-risk groups and the risk of reinfection. J Hepatol. 2016;65(1 Suppl):S33–S45. PMID: 27641987 PubMed
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