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Stevens-Johnson syndrom og toksisk epidermal nekrolyse

Stevens-Johnson syndrom og toksisk epidermal nekrolyse er sjeldne, akutte, livstruende hudsykdommer som viser seg ved utbredt løsning av hudoverflaten. Tilstandene er oftest forårsaket av et legemiddel.

Medikamentell behandling

Sist oppdatert:

19. mars 2019

Innhold i artikkelen

Hva er Stevens-Johnson syndrom og toksisk epidermal nekrolyse?

Stevens-Johnson syndrom og toksisk epidermal nekrolyse er sjeldne, akutte, livstruende hudsykdommer som viser seg ved utbredt løsning av hudoverflaten (epidermis) fra underhuden, og kraftig utslett/betennelse i slimhinner, ledsaget av feber og varierende grad av sykdom også i indre organer. Tilstanden er oftest forårsaket av et legemiddel. Tidlig diagnose, stans av behandlingen med det utløsende legemiddel og relevant støttebehandling er avgjørende for om pasienten overlever.

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Stevens-Johnsons syndrom (SJS) og toksisk epidermal nekrolyse (TEN) er samme sykdom, men SJS har mindre omfattende hudskade. Ved SJS ser man løsning/avflakning av mindre enn ti prosent av hudoverflaten, mens ved toksisk epidermal nekrolyse (TEN) omfattes mer enn 30 prosent av huden.

Det oppstår cirka fire til syv tilfeller per en million mennesker per år. I Norge ble det i 2013 meldt tre tilfeller av den alvorligste formen (TEN).

Tilstanden kan opptre i alle aldersgrupper, men den ses oftest hos eldre personer, beinmargstransplanterte og pasienter med systemisk lupus erytematosus eller HIV-infeksjon.

Dette dokumentet er basert på det profesjonelle dokumentet Stevens-Johnson syndrom og toksisk epidermal nekrolyse . Referanselisten for dette dokumentet vises nedenfor

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