Magnesium, terapi: Magnesiummangel
Tidlige tegn på magnesiummangel er tap av matlyst, kvalme, brekninger, slapphet og svakhet. Noen klager over nummenhet og prikking i armer og ben, muskelspenninger og muskelkramper, epileptiske anfall, personlighetsendringer. Tilstanden kan også forårsake unormale hjerterytmer og sammentrekninger (spasmer) i koronararteriene til hjertet, noe som gir angina pectoris. Dilemmaet er at dette er diffuse og vage symptomer som kan ha mange andre forklaringer. Alvorlig magnesiummangel kan føre til lavt nivå av kalsium og kalium i kroppen.
Tilstander som disponerer for magnesiummangel, er dårlig kontrollert diabetes, kroniske betennelsessykdommer i tarmen (eks. Crohns sykdom, cøliaki), bruk av vanndrivende midler og antibiotika, alkoholisme og høy alder.
Normalverdier: Begge kjønn: 0,71 - 0,94 mmol/L.
- Guerrera MP, Volpe SL, Mao JJ. Therapeutic uses of magnesium. Am Fam Physician 2009; 80: 157-62. American Family Physician
- Alaimo K, McDowell MA, Briefel RR, et al. Dietary intake of vitamins, minerals, and fiber of person ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988-91. Adv Data 1994;(258): 1–28.
- Guerrero-Romero F, Rodriguez-Moron M. Hypomagnesemia is linked to low serum HDL-cholesterol irrespective of serum glucose values. J Diabetes Complications 2000; 14: 272-6. PubMed
- Elin RJ. Magnesium: the fifth but forgotten electrolyte. Am J Clin Pathol 1994; 102: 616-22. PubMed
- Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res 2004; 17: 126-36. PubMed
- Bohl CH, Volpe SL. Magnesium and exercise. Crit Rev Food Sci Nutr 2002; 42: 533-63. PubMed
- Chubanov V, Gudermann T, Schlingmann KP. Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch 2005; 451: 228-34. PubMed
- Witlin AG, Sibai BM. Magnesium sulfate therapy in preeclampsia and eclampsia. Obstet Gynecol 1998; 92: 883-9. PubMed
- Duley L, Gulmezoglu AM. Magnesium sulphate versus lytic cocktail for eclampsia. Cochrane Database Syst Rev, issue 1, 2001. CD002960. Cochrane (DOI)
- Duley L, Gulmezoglu AM, Henderson-Smart DJ. Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev, issue 2, 2003. CD000025. Cochrane (DOI)
- Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 2002; 359: 1877-90. PubMed
- Banai S, Tzivoni D. Drug therapy for torsade de pointes. J Cardiovasc Electrophysiol 1993; 4: 206-10. PubMed
- Onalan O, Crystal E, Daoulah A, Lau �C, Crystal A, Lashevsky I. Meta-analysis of magnesium therapy for the acute management of rapid atrial fibrillation. Am J Cardiol 2007; 99: 1726-32. PubMed
- Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA �Jr. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev, issue 2, 2000. CD001490. Cochrane (DOI)
- Mauskop A, Altura BT, Altura BM. Serum ionized magnesium levels and serum ionized calcium/ionized magnesium ratios in women with menstrual migraine. Headache 2002; 42: 242-8. PubMed
- Pfaffenrath V, Wessely P, Meyer C, et al. Magnesium in the prophylaxis of migraine–a double-blind placebo-controlled study. Cephalalgia 1996; 16: 436-40. PubMed
- Bigal ME, Bordini CA, Tepper SJ, Speciali JG. Intravenous magnesium sulphate in the acute treatment of migraine without aura and migraine with aura. A randomized, double-blind, placebo-controlled study. Cephalalgia 2002; 22: 345-53. PubMed